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通过左侧精索静脉主干结扎和左肾静脉部分结扎诱导SD大鼠精索静脉曲张成功后,利用透射电子显微镜对其睾丸,附睾的超微结构进行了研究。结果表明:精索静脉曲张所致睾丸、附睾超微结构的改变为双侧性。最常见的病变为支持细胞滑面内质网扩张或形成空泡;还常见到精子细胞核内基质空化,核膜破裂,线粒体鞘局部缺损。附睾柱状上皮细胞静纤毛稀少、局部缺乏。证实了支持细胞异常为导致生精细胞发育终止和过早释放的重要原因;也为附睾在精索静脉曲张源性不育中的作用提供了重要的形态学基础。
Through the left main suture of the varicocele and partial ligation of the left renal vein to induce the success of varicocele in SD rats, the ultrastructure of the testis and epididymis were studied by transmission electron microscopy. The results showed that: varicocele caused by changes in testicular and epididymis ultrastructure of bilateral. The most common lesion is to support cell smooth surface endoplasmic reticulum dilation or vacuolization; also often found in the sperm cell nucleus matrix cavitation, nuclear membrane rupture, mitochondrial sheath local defect. Epididymal columnar epithelial cells sparse cilia, local lack of. It is confirmed that the abnormality of supporting cells is the important reason leading to the termination and premature release of spermatogenic cells. It also provides an important morphological basis for the role of epididymis in varicocele-derived sterility.