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从芸香科植物芸香(Ruta graveolens)中曾分离得大量香豆精和生物碱类成分,在预初体外试验中,显示某些分离物有解痉活性。近来从大量植物样品中重复分离到足够量的某些成分,得以进一步研究。将雌性CEy大白鼠胃底条片和回肠部剪下的肠段,雄性豚鼠及新西兰家兔的离体回肠,以及猪的离体冠状血管条悬垂于38°且通有95%氧和5%二氧化碳混合气体的生理溶液中,在不同浓度拮抗剂存在下,按照对激动剂量大反应的抑制程度计算PD_2值。结果发现,rutamarin及arborinine作用于大鼠
A large number of coumarins and alkaloids have been isolated from the Ruta graveolens Rutaceae plants. In preliminary in vitro tests, some of the isolates showed antispasmodic activity. Recently, a large number of plant samples were repeatedly isolated a sufficient amount of certain components for further study. Female CEy rat gastric fundus strips and the ileum section of the intestine removed, male guinea pigs and New Zealand rabbit isolated ileum, and porcine isolated coronary vessels suspended at 38 ° and with 95% oxygen and 5% CO2 gas mixture of physiological solution, in the presence of different concentrations of antagonist, according to the degree of inhibition of agonist dose response calculated PD2 value. The results showed that, rutamarin and arborinine role in rats