【摘 要】
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Neuroinflammation and α-synuclein(α-syn)aggregation are both neuropathological hallmarks of Parkinson's dis-ease(PD).Microglia are crucial participants in eli
【机 构】
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Department of Physiology,Shandong Provincial Key Labo-ratory of Pathogenesis and Prevention of Neuro
论文部分内容阅读
Neuroinflammation and α-synuclein(α-syn)aggregation are both neuropathological hallmarks of Parkinson's dis-ease(PD).Microglia are crucial participants in eliciting neuroinflammatory responses themselves,as well as mod-ulating neurotoxic activity in astrocytes,therefore forming a pathway to neurodegeneration induced by both central and peripheral insults[1,2].Microglia are supposed to express low levels of α-syn,which is physiologically functional in membrane-associated processes at the presy-naptic level in neurons.However,the cell-to-cell(prion-like)transmission of pathological proteins in neurodegen-erative diseases[3],such as α-syn in PD,prompts the investigation of α-syn handling by microglia.
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