论文部分内容阅读
目的探讨环氧化酶-2(COX-2)在幽门螺杆菌(Hp)感染与非感染性胃溃疡及胃癌的表达。方法选择绵阳市404医院消化内科2011年2月-2012年2月的门诊及住院患者,用免疫组织化学方法检测196例经胃镜和组织病理学检查明确为胃溃疡(病理分型:肠上皮化生、异型增生)、胃癌及正常胃黏膜者的胃黏膜COX-2蛋白的表达,比较各病理分类之间及Hp感染与非感染之间COX-2蛋白表达的差异。结果胃溃疡(肠上皮化生、异型增生)、胃癌组的炎症细胞、腺上皮细胞、癌细胞及极少量正常黏膜上皮细胞中有COX-2表达。从正常胃黏膜-胃溃疡(肠上皮化生、异型增生)-胃癌COX-2的阳性表达有逐渐增强的趋势(P<0.05)。Hp阳性组COX-2的阳性表达高于Hp阴性组(P<0.05),胃癌组COX-2的阳性表达高于胃溃疡组(P<0.05)。结论 COX-2在胃癌的表达高于胃溃疡。Hp感染可诱导COX-2过度表达。
Objective To investigate the expression of cyclooxygenase-2 (COX-2) in Helicobacter pylori (Hp) infection and non-infectious gastric ulcer and gastric cancer. Methods Outpatients and inpatients from Department of Gastroenterology, 404 Hospital of Mianyang City from February 2011 to February 2012 were enrolled in this study. 196 cases of gastric ulcer were identified by gastroscopy and histopathological examination by immunohistochemistry (pathological type: intestinal metaplasia , Dysplasia, gastric cancer and normal gastric mucosa. The differences of COX-2 protein expression between Hp infection and non-infection were compared. Results Gastric ulcer (intestinal metaplasia, dysplasia), gastric cancer group of inflammatory cells, glandular epithelial cells, cancer cells and a very small amount of normal mucosal epithelial cells have COX-2 expression. From the normal gastric mucosa - gastric ulcer (intestinal metaplasia, dysplasia) - gastric cancer COX-2 positive expression gradually increased trend (P <0.05). The positive expression of COX-2 in Hp positive group was higher than that in Hp negative group (P <0.05). The positive expression of COX-2 in gastric cancer group was higher than that in gastric ulcer group (P <0.05). Conclusion The expression of COX-2 in gastric cancer is higher than that in gastric ulcer. Hp infection can induce COX-2 overexpression.