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目的探讨恶性黑色素瘤(MM)的临床及病理特征,提高其早期的诊断率。方法回顾性分析38例恶性黑色素瘤患者的临床资料及病理特征。结果 38例患者均为中老年人,肿瘤发生于全身多处部位,以四肢皮肤多见;免疫组化结果及阳性率显示:vimentin、Melan-A、S-100、HMB45阳性率分别为100.0%(28/28)、95.0%(19/20)、89.5%(17/19)、85.0%(17/20),AE1/AE3全部为阴性,ki-67全部为阳性。结论恶性黑色素瘤是一种少见的高度恶性肿瘤,发病较隐匿,发病部位较广泛,病理组织结构复杂多样,极易误诊;免疫组化抗体中HMB45、Melan-A、S-100具有重要诊断意义,vimentin、AE1/AE3、LCA、ki-67具有重要鉴别诊断价值。
Objective To investigate the clinical and pathological features of malignant melanoma (MM) and to improve its early diagnosis rate. Methods The clinical data and pathological features of 38 patients with malignant melanoma were retrospectively analyzed. Results The 38 patients were all middle-aged and old. The tumor occurred in multiple parts of the body and was more common in the limbs. The positive rate of immunohistochemistry and immunohistochemistry showed that the positive rates of vimentin, Melan-A, S-100 and HMB45 were 100.0% (28/28), 95.0% (19/20), 89.5% (17/19) and 85.0% (17/20) respectively. All AE1 / AE3 were negative and all ki-67 was positive. Conclusions Malignant melanoma is a rare and highly malignant tumor with relatively insidious onset, extensive disease location and complex and diverse pathological structures, which can be easily misdiagnosed. HMB45, Melan-A and S-100 in immunohistochemical antibodies are of great diagnostic significance , vimentin, AE1 / AE3, LCA, ki-67 has important diagnostic value.