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本文对50例肝细胞肝癌和9例正常肝的核仁组成区蛋白嗜银染色(AgNOR)进行比较研究。每一例标本均计数100个细胞的AgNOR数目,结果看到分化差肝癌AgNOR数为8.24±2.44((?)±SD,下同)、最大直径0.78±0.18μm、面积0.41±0.18μm~2;分化中肝癌AgNOR数为6.51±1.45、最大直径1.63±0.37μm、面积1.90±0.18μm~2;分化好肝癌AgNOR数为5.74±1.52、最大直径2.46±0.51μm、面积4.33±1.70μm~2;正常肝AgNOR数为1.15±0.05、最大直径2.27±0.25μm、面积3.90±0.62μm~2。肝细胞肝癌与正常肝细胞之间,在AgNOR数目、最大直径与面积方面的差别均非常显著(P<0.001)。不同分化程度的肝癌之间,最大直径与面积的差别也非常显著(P<0.001)。
In this paper, AgNOR was compared in 50 cases of hepatocellular carcinoma and 9 cases of normal liver. The number of AgNORs in 100 specimens was counted in each specimen. The results showed that the AgNOR number of differentially differentiated hepatoma was 8.24±2.44 ((?)±SD, the same below), the maximum diameter was 0.78±0.18 μm, and the area was 0.41±0.18 μm 2 . The AgNOR count of hepatocellular carcinoma was 6.51±1.45, the maximum diameter was 1.63±0.37μm, and the area was 1.90±0.18μm~2. The AgNOR count of well differentiated hepatoma was 5.74±1.52, the maximum diameter was 2.46±0.51μm, and the area was 4.33±1.70μm~2. The normal liver AgNOR count was 1.15±0.05, the maximum diameter was 2.27±0.25 μm, and the area was 3.90±0.62 μm~2. The difference in the number of AgNORs, the maximum diameter and the area between hepatocellular carcinoma and normal hepatocytes was very significant (P<0.001). The difference in the maximum diameter and area between the different degrees of differentiation of liver cancer is also very significant (P <0.001).