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目的：了解人胎儿消化系统生长抑素（ＳＳ）发生、发展及分布规律．方法：应用放射免疫分析法（ＲＩＡ）系统测定１５例胎儿消化系统各组织中的ＳＳ浓度．结果：在人胚胎胃肠胰组织中均有不同浓度的ＳＳ存在，ＳＳ在消化系统出现的时间均早于１６周，２２周后呈典型成人型分布．ＳＳ含量以胰腺最高，依次为十二指肠、胃；食管、回肠、结肠、胆囊含量较低，与前者比较Ｐ＜０．０５．随胚胎发育，ＳＳ发展呈三种趋势：①胃、十二指肠、胰腺ＳＳ逐渐升高，与胎龄呈正相关（ｒ分别为０．８０７７，０．６７９３，０．８８３１，Ｐ均＜０．０１）；②食管、回肠、结肠、胆囊等ＳＳ波动在一定水平，无显著变化；③贲门、幽门、空肠、盲肠ＳＳ呈下降或先上升后下降趋势．此外，还首次发现阑尾存在较高浓度的ＳＳ，其水平与胎龄呈负相关（ｒ＝－０．７８８９，Ｐ＜０．０１）．结论：人胎儿消化系统ＳＳ的发生与分布具有一定的规律性．通过测定胃、十二指肠、胰腺、阑尾等的ＳＳ浓度可能有助于判断胎儿的发育情况
Objective: To understand the occurrence, development and distribution of somatostatin (SS) in human fetal digestive system. Methods: Radioimmunoassay (RIA) was used to determine the concentration of SS in 15 cases of fetal digestive system. Results: There were different concentrations of SS in human embryo gastrointestinal and pancreatic tissues. SS occurred earlier than 16 weeks in the digestive system and typical adult distribution after 22 weeks. The content of SS was highest in pancreas, followed by duodenum and stomach. The content of SS, esophagus, ileum, colon and gallbladder was lower than that of the former (P <0.05). With the development of embryos, there were three trends in the development of SS: ①Standings of the stomach, duodenum and pancreas increased gradually with a positive correlation with gestational age (r = 0.8077,0.6793,0.8831, P <0 .01). ② The SS of esophagus, ileum, colon, gallbladder and so on fluctuated at a certain level with no significant change. ③The SS, pylorus, jejunum and cecum SS decreased or rose first and then decreased. In addition, it was also found for the first time that there was a high concentration of SS in the appendix with a negative correlation with gestational age (r = -0.7889, P <0.01). Conclusion: The occurrence and distribution of SS in human fetal digestive system have certain regularity. By determining the SS concentration of the stomach, duodenum, pancreas, appendix, etc. may be helpful in judging the development of the fetus