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从无色素细菌中分离出的谷酰胺酶,实验证明能杀灭慢性淋巴细胞性和急性白血病的白血细胞,并能抑制正常淋巴细胞对植物血凝素的反应。本文报道应用谷酰胺酶治疗急性白血病的情况。接受治疗者共9例,其中6例为急性淋巴细胞性白血病,3例急性粒细胞性白血病,均在缓解一至数次后复发,并对最有效的抗白血病药物和8种药物联合化疗产生抗药性。剂量每天3,500～20,000国际单位/平方米~2静脉推注或持续点滴。治疗后一般1周内,肿大的脾脏缩小,外周血液中母细胞计数明显降低,骨髓母细胞比率下降,自觉症状改善,但没有1例缓解,可能因处于疾病的晚期,对其他抗白血病药物已失效。本药的副作用在治疗初期主要是恶心,呕吐,一般数天后消失。少数患者出现嗜睡,有的病人用药后血清尿酸、重碳酸钠、胆固醇、血清谷草转氨酶及血
Glutaminase isolated from a pigment-free bacterium has been shown to kill white blood cells of chronic lymphocytic and acute leukemia and to inhibit the response of normal lymphocytes to phytohemagglutinin. This article reports the treatment of acute leukemia with glutamine. A total of 9 patients were treated, of which 6 cases of acute lymphoblastic leukemia, 3 cases of acute myeloid leukemia, were all relieved one to several times after the recurrence, and the most effective anti-leukemia drugs and 8 drugs combined with chemotherapy-resistant Medicinal properties. Dose 3,500 ~ 20,000 IU / m2 ~ 2 intravenous injection or continuous drip. Within 1 week after treatment, the swollen spleen was reduced, the count of blast cells in peripheral blood was significantly decreased, the rate of bone marrow cells was decreased and the symptoms were improved. However, no one was relieved. In the late stage of the disease, other antileukemic drugs expired. The side effects of this drug in the initial treatment is mainly nausea, vomiting, usually disappear after a few days. A few patients appear lethargy, and some patients after treatment of serum uric acid, sodium bicarbonate, cholesterol, serum aspartate aminotransferase and blood