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目的 观察血清白细胞介素6(IL-6)在胎膜早破(PROM)孕妇中的表达,探讨其与破膜时间和宫内感染的关系。方法 选取2014年1月-2016年12月于医院妇产科检查并住院分娩的200例孕妇为研究对象,其中PROM孕妇140例为实验组,足月未胎膜早破的正常分娩孕妇60例为对照组;实验组包括足月前胎膜早破(PPROM)孕妇70例和足月胎膜早破(TPROM)孕妇70例;比较两组患者临床指标。结果 实验组血清WBC、CRP和IL-6表达均高于对照组(P<0.05);实验组宫内感染率29.3%,高于对照组宫内感染率1.7%(P<0.05);实验组中合并宫内感染者血清WBC、CRP和IL-6表达均高于无宫内感染者(P<0.05);TPROM合并宫内感染者血清WBC和CRP表达高于无宫内感染者(P<0.05);PPROM合并宫内感染者血清WBC、CRP和IL-6表达高于无宫内感染者(P<0.05);与破膜时间<24h的孕妇比较,宫内感染发生率、血清CRP和IL-6表达在破膜时间>24h的孕妇明显增高(P<0.05)。结论 血清IL-6水平与PROM孕妇宫内感染、破膜时间长短密切相关。
Objective To observe the expression of serum interleukin-6 (IL-6) in pregnant women with premature rupture of membranes (PROM) and to explore the relationship between IL-6 and rupture time and intrauterine infection. Methods From January 2014 to December 2016, 200 pregnant women who were hospitalized in obstetrics and gynecology department and hospitalized for delivery were enrolled in this study. Among them, 140 cases of PROM pregnant women were the experimental group, 60 cases of normal delivery pregnant women without adequate premature rupture of membranes As control group. The experimental group included 70 preterm premature rupture of membranes (PPROM) pregnant women and 70 full term premature rupture of membranes (TPROM) pregnant women. The clinical indexes of the two groups were compared. Results The serum levels of WBC, CRP and IL-6 in the experimental group were significantly higher than those in the control group (P <0.05). The intrauterine infection rate in the experimental group was 29.3%, higher than that in the control group (1.7%, P <0.05) (P <0.05). The expression of serum WBC, CRP and IL-6 in intrauterine infection group were higher than those without intrauterine infection (P < 0.05). The levels of serum WBC, CRP and IL-6 in PPROM with intrauterine infection were higher than those without intrauterine infection (P <0.05). The incidences of intrauterine infection, serum CRP, The expression of IL-6 in the rupture time of 24h pregnant women was significantly higher (P <0.05). Conclusions Serum IL-6 levels are closely related to intrauterine infection and the duration of rupture of membranes in PROM pregnant women.