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目的:探讨ASC-US患者HPV-DNA分型检测的临床意义。方法:对2008年1月～2010年1月在桂林医学院附属医院妇产科同时行宫颈细胞学筛查以及HPV-DNA分型检测其中宫颈细胞学结果判读为ASC-US的138例患者的相关资料进行分析。结果:138例ASC-US患者中HPV-DNA分型检测高危亚型阳性者61例,占44.20%,其中HPV-DNA16或(和)58亚型阳性者46例,占总数的33.33%,占高危阳性的75.41%。HPV-DNA高危亚型阳性对CINⅡ及以上病变检出的敏感度为91.67%,特异度为60.32%,对CINⅡ及以上者的阴性预测值为98.70%。HPV-DNA16/58亚型阳性对CINⅡ及以上病变检出的敏感度为58.33%,特异度为69.05%。结论:HPV-DNA分型检测在ASC-US患者分层处理中有意义,对HPV-DNA分型检测高危阳性患者需行阴道镜检查,其余可用宫颈细胞学随诊。
Objective: To investigate the clinical significance of HPV-DNA typing in ASC-US patients. Methods: From January 2008 to January 2010, simultaneous cervical cytology screening and HPV-DNA typing were performed in the department of Obstetrics and Gynecology of the Affiliated Hospital of Guilin Medical College from January 2008 to January 2010, and 138 patients with cervical cytological findings interpreted as ASC-US Related information for analysis. Results: Among 138 ASC-US patients, 61 cases (44.20%) were HPV-DNA positive, of which 46 were positive for HPV-DNA16 or (and) 58 subtypes, accounting for 33.33% of the total High-risk positive 75.41%. The positive rate of HPV-DNA high-risk subtypes was 91.67%, the specificity was 60.32% and the negative predictive value was 98.70% for CINⅡand above. The positive rate of HPV-DNA16 / 58 subtype was 58.33% and the specificity was 69.05%. CONCLUSION: HPV-DNA typing is of significance in the stratification of ASC-US patients. Colposcopy should be performed on high-risk HPV-DNA typing and the remaining cervical cytology should be followed up.