论文部分内容阅读
目的评价低剂量雌激素替代疗法治疗围绝经期综合征(PMS)疗效及对患者体内激素水平的影响。方法选取2014年4月至2015年12月PMS患者164例,随机分为两组。对照组82例,给予患者口服孕激素甲羟孕酮治疗;观察组82例,在对照组基础上实施雌激素戊酸雌二醇片治疗。对比两组临床疗效,并观察患者治疗前后激素水平、内膜厚度及子宫体积变化。结果观察组临床总有效率为93.90%,高于对照组(60.98%),差异有统计学意义(P<0.05);治疗后观察组E2水平较对照组升高,LH、FSH水平较对照组降低,差异有统计学意义(P<0.05);两组患者治疗后子宫体积较治疗前降低,内膜厚度较治疗前升高,差异未见统计学意义(P>0.05)。结论给予围绝经期综合征患者低剂量雌激素替代疗法治疗,可有效促进体内激素分泌正常化,缓解临床症状,提高临床疗效。
Objective To evaluate the effect of low-dose estrogen replacement therapy on perimenopausal syndrome (PMS) and its effect on hormone levels in patients. Methods 164 patients with PMS from April 2014 to December 2015 were randomly divided into two groups. 82 cases in the control group were treated with progestin and medroxyprogesterone acetate. In the observation group, 82 cases were treated with estradiol valerate valerate on the basis of the control group. The clinical efficacy was compared between the two groups, and the changes of hormone levels, intima-media thickness and uterine volume before and after treatment were observed. Results The total clinical effective rate in observation group was 93.90%, higher than that in control group (60.98%), the difference was statistically significant (P <0.05). After treatment, E2 level in observation group was higher than that in control group, LH and FSH levels were higher than those in control group (P <0.05). After treatment, the uterine volume of both groups decreased after treatment, and the thickness of intima increased compared with that before treatment. The difference was not statistically significant (P> 0.05). Conclusions The low-dose estrogen replacement therapy for patients with perimenopausal syndrome can effectively normalize hormone secretion, relieve clinical symptoms and improve clinical efficacy.