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目的观察胃印戒细胞癌癌前病变及癌变形态发生．方法全切除胃印戒细胞癌标本６８例，常规固定，包埋制片，光镜检查．结果腺管增殖带延长３５例，颈粘液细胞依次变为小立方形细胞（Ⅰ型细胞）、中等大小组织细胞样细胞（Ⅱ型细胞）及典型印戒细胞（Ⅲ型细胞）；见到球样异型增生灶１６例；癌细胞始发为Ⅱ型细胞６例；管状腺癌演变为印戒细胞２例．结论胃印戒细胞癌的形态发生可能有数种途径．印戒细胞癌与肠化关系应进一步探明
1. Objective To observe the precancerous changes and carcinogenesis of gastric signet ring cell carcinoma. Methods Totally 68 cases of gastric signet ring cell carcinoma were completely resected. The routine fixation, embedding and light microscopy were performed. RESULTS: The proliferative zone of the ducts was prolonged in 35 cases. The cervical mucous cells were changed into small cubic cells (type I cells), medium-sized histiocyte-like cells (type II cells), and typical signet ring cells (type III cells); There were 16 cases of heterogeneous hyperplasia; 6 cases of type II cells were originated from cancer cells; tubular adenocarcinomas evolved into signet ring cells in 2 cases. Conclusion There may be several ways of morphogenesis of gastric signet ring cell carcinoma. Signet ring cell cancer and intestinal metastasis should be further proved