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目的探讨血液透析(HP)联合血液灌流(HD)对终末期肾衰患者中大分子的影响。方法对南阳医学高等专科学院第一附属医院的48例终末期肾衰患者进行研究,随机分为对照组(24例)和研究组(24例),前者仅给予HD治疗,后者在HD基础上给予HP,分析治疗前后的血液中大分子情况及清除率。结果研究组治疗后的PTH(P<0.01)、LEP(P<0.05)以及β2-MG(P<0.01)水平低于对照组。结论联合处理可降低终末期肾衰患者中大分子水平,可在相关治疗中进行推广。
Objective To investigate the effect of hemodialysis (HP) combined with hemoperfusion (HD) on macromolecules in patients with end-stage renal failure. Methods Forty-eight patients with end-stage renal failure in the First Affiliated Hospital of Nanyang Medical College were studied and randomly divided into control group (24 cases) and study group (24 cases). The former was treated with HD only, On the given HP, analysis of blood before and after treatment of macromolecules and clearance rate. Results The levels of PTH (P <0.01), LEP (P <0.05) and β2-MG (P <0.01) in the study group were lower than those in the control group. Conclusion Combined treatment can reduce the level of macromolecules in patients with end-stage renal failure, which can be promoted in the relevant treatment.