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目的分析急性冠脉综合征(ACS)患者血清中可溶性CD40配体(sCD4OL)、可溶性P选择素(sCD4OL)水平变化及临床意义。方法选取ACS患者38例,稳定型心绞痛(SAP)患者32例及健康体检者20例,采用酶联免疫法测定其血清sCD4OL、sP-selectin水平,分析sCD4OL与sP-selectin的相关性。结果 ACS组血清sCD4OL(47.93±12.30)、sP-selectin(5340±123)水平均显著高于SAP组(2.57±1.23)、(1618±117)和对照组(2.11±0.86)、(1582±124),差异有显著性(均P<0.05),SAP组与对照组比较则差异无显著性(均P>0.05)。ACS患者血清sCD4OL与sP-selectin呈显著正相关(r=0.516,P<0.05)。结论 ACS患者血清sCD4OL和sP-selectin水平均明显升高,它们共同作用促进ACS的发生和发展。
Objective To analyze the changes of serum soluble CD40 ligand (sCD4OL), soluble P-selectin (sCD4OL) and its clinical significance in patients with acute coronary syndrome (ACS). Methods 38 patients with ACS, 32 patients with stable angina pectoris (SAP) and 20 healthy subjects were enrolled in this study. Serum levels of sCD4OL and sP-selectin were measured by enzyme linked immunosorbent assay (ELISA), and the correlation between sCD4OL and sP-selectin was analyzed. Results The serum levels of sCD4OL (47.93 ± 12.30) and sP-selectin (5340 ± 123) in ACS group were significantly higher than those in SAP group (2.57 ± 1.23), (1618 ± 117) and control group (2.11 ± 0.86) ), The difference was significant (all P <0.05), there was no significant difference between SAP group and control group (all P> 0.05). There was a significant positive correlation between serum sCD4OL and sP-selectin in ACS patients (r = 0.516, P <0.05). Conclusions Serum levels of sCD4OL and sP-selectin in patients with ACS were significantly increased, and their synergistic effect promoted the occurrence and development of ACS.