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The positron-emitter fluorine-18 labeled amino acid O-(2-[18F]fluoroethyl)-L-tyrosine ([18F]FET) has shown very promising perspectives for brain tumor diagnosis with positron emission tomography (PET). There have been two existing preparation routes of [18F]FET named direct nucleophilic radiofluorination of protected L-tyrosine and radiofluoroalkylation of unprotected L-tyrosine, respectively. A general module was designed specifically for the routine synthesis of [18F]FET, which could be suitable for the present two chemical methods with simple modifica- tions. The fluorinated intermediates and the final product were separated and purified using solid phase extraction (SPE) on the Sep-Pak silica plus cartridge instead of the time-consuming high performance liquid chromatography (HPLC) procedures. The total synthesis time was about 50—60 min with good radiochemical yield (about 20—40%, no-decay-corrected) and good radiochemical purity (more than 97%) for both the synthetic methods.
The positron-emitter fluorine-18 labeled amino acid O- (2- [18F] fluoroethyl) -L-tyrosine ([18F] FET) has shown very promising perspectives for brain tumor diagnosis with positron emission tomography Two existing preparation routes of [18F] FET named direct nucleophilic radiofluorination of protected L-tyrosine and radiofluoroalkylation of unprotected L-tyrosine, respectively. A general module was designed specifically for the routine synthesis of [18F] FET, which could be suitable for the present two chemical methods with simple modifica- tions. The fluorinated intermediates and the final product were separated and purified using solid phase extraction (SPE) on the Sep-Pak silica plus cartridge instead of time-consuming high performance liquid chromatography (HPLC) procedures . The total synthesis time was about 50-60 min with good radiochemical yield (about 20-40%, no-decay-corrected) and good radiochemical purity (more than 97%) for both the synthetic methods.