以水为溶剂,碳酸铯为碱,在草酸钴二水合物/N,N’-二甲基乙二胺催化下,脂肪酰胺和碘代芳烃发生C-N交叉偶联生成相应的N-芳基脂肪酰胺,25例收率40%~85%。碘代芳烃邻位有位阻较大的基团时产率降低,间对位取代均有较好收率,乙(或丙)酰胺不能反应,溴代芳烃也不反应。 Using water as the solvent and cesium carbonate as the base, CN cross-coupling of fatty acid amides and iodo-substituted aromatics to give the corresponding N-aryl fats catalyzed by cobalt oxalate dihydrate / N, N’-dimethylethylenediamine Amide, 25 cases yield 40% ~ 85%. When the ortho-substituted iodoaromatic group has a larger steric hindrance, the yield decreases, and the para-para substitution has better yield. The B (or C) amide can not react and the bromo-substituted aromatic does not react.