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目的:探讨双歧杆菌四联活菌片对肝硬化患者肝功能、Child-Pugh评分及肠道通透性的影响。方法:72例肝硬化患者随机分为对照组和观察组。两组患者均予以肝硬化常规治疗,观察组在上述基础上口服双歧杆菌四联活菌片1.5g,tid,治疗4周。治疗前后观察两组患者肝功能、Child-Pugh评分及肠道通透性的变化。结果:治疗4周后,两组患者ALT、AST和Child-Pugh评分均较治疗前明显下降(P<0.05或0.01),且观察组下降的幅度较对照组更明显。两组患者血浆二胺氧化酶和内毒素水平均较治疗前明显下降(P<0.05或0.01),且观察组下降的幅度较对照组更明显(P<0.05)。结论:双歧杆菌四联活菌片可有效降低肠道通透性,改善肠黏膜屏障功能和肝功能,对肝硬化有辅助治疗作用。
Objective: To investigate the effects of Bifidobacterium quadriceps on liver function, Child-Pugh score and intestinal permeability in cirrhotic patients. Methods: Seventy-two patients with cirrhosis were randomly divided into control group and observation group. Two groups of patients were treated with conventional cirrhosis, the observation group on the basis of oral Bifidobacterium quadruple live 1.5g tablets, tid, for 4 weeks. Before and after treatment, liver function, Child-Pugh score and intestinal permeability of the two groups were observed. Results: After 4 weeks of treatment, the ALT, AST and Child-Pugh scores of both groups were significantly lower than those before treatment (P <0.05 or 0.01), and the extent of decrease in the observation group was more obvious than that in the control group. Plasma diamine oxidase and endotoxin levels in both groups were significantly lower than those before treatment (P <0.05 or 0.01), and the extent of decrease in the observation group was more significant than that in the control group (P <0.05). Conclusion: Bifidobacterium quadriceps can effectively reduce intestinal permeability, improve intestinal mucosal barrier function and liver function, and has an adjuvant therapeutic effect on cirrhosis.