论文部分内容阅读
目的分析丙型肝炎并肝细胞肝癌的临床病理特征,以期减少误诊和漏诊。方法将12例丙型肝炎并肝细胞肝癌患者的病变肝组织做病理切片、HE染色及免疫组化检测,光镜下观察。结果 12例肝细胞癌中:6例中-低分化,4例中分化,2例低分化。12例周围肝中:8例呈完全分割型结节性肝硬化,2例早期肝硬化,2例纤维增生致小叶结构紊乱。12例经免疫组化检测HCV阳性者11例。其中,10例癌及癌旁组织点灶状阳性,1例癌及癌旁散在阳性,1例癌组织弥漫阳性,周围肝灶状阳性。结论丙型肝炎肝组织多呈中度炎症反应,早期即可发生肝纤维化,肝功能血清酶学改变可与病理改变程度不一致,并发肝细胞肝癌分化较差,易侵犯血管,恶性度高。
Objective To analyze the clinicopathological features of hepatitis C and hepatocellular carcinoma in order to reduce misdiagnosis and missed diagnosis. Methods Pathological sections of 12 diseased liver tissues from patients with hepatitis C and hepatocellular carcinoma were made. HE staining and immunohistochemistry were used to observe the pathological changes. Results In 12 cases of hepatocellular carcinoma, 6 cases were moderate-poorly differentiated, 4 cases moderately differentiated and 2 cases poorly differentiated. Among the 12 cases, there were 8 cases of complete nodular cirrhosis, 2 cases of early cirrhosis, and 2 cases of fibrous dysplasia. Twelve cases were detected by immunohistochemistry in 11 cases of HCV positive. Among them, 10 cases of cancer and paracancerous tissue focal spots were positive, 1 case of cancer and adjacent to the tumor were scattered in the positive, 1 case of cancer was diffuse positive, around the liver focus was positive. Conclusions Hepatic fibrosis of hepatitis C is mostly moderately inflammatory. Liver fibrosis can occur in the early stage. Serum enzymological changes of hepatic function may be inconsistent with pathological changes. Hepatocellular carcinoma is poorly differentiated and prone to violate blood vessels with high malignancy.