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目的:观察高强度聚焦超声(HIFU)联合复方苦参注射液(FKS)治疗中晚期肝癌(HCC)疗效。方法:79例中晚期HCC随机分两组,HIFU+FKS组采用HIFU,1次/d,连续5天,根据病灶大小制定相应剂量,5%GS(或0.9%NS)250 m L+复方苦参注射液15 m L静点,1次/d,连续10天;单独HIFU组治疗,1次/d,连续5天,同样根据病灶大小制定相应计划。结果:HIFU+FKS组PR 22例,SD8例,PD7例,RR59.46%,DCR 81.08%,PFS 8.2个月;单独HIFU组,PR14例,SD11例,PD17例,RR33.33%,DCR 59.52%,PFS 5.3个月。HIFU+FK组在有效率、疾病无进展生存期、疾病控制率等方面均优于单独HIFU组(P<0.05)。结论:HIFU+FKS治疗中晚期肝癌疗效好,不良反应可耐受。
Objective: To observe the effect of high intensity focused ultrasound (HIFU) combined with Compound Kushen Injection (FKS) in the treatment of advanced hepatocellular carcinoma (HCC). Methods: 79 cases of advanced HCC were randomly divided into two groups. HIFU + FKS group was given HIFU once a day for 5 consecutive days. The corresponding dose of 5% GS (or 0.9% NS) 250 m L + Compound Sophora flavescens Injection 15 m L static point, 1 time / d, continuous 10 days; HIFU group alone treatment, 1 / d, for 5 days, the same according to the size of the lesion to develop the appropriate plan. Results: HIFU + FKS group had 22 cases of PR, 8 cases of SD, 7 cases of PD, RR of 59.46%, DCR of 81.08% and PFS of 8.2 months. HIFU alone group, PR 14 cases, SD 11 cases, PD 17 cases, RR 33.33%, DCR 59.52 %, PFS 5.3 months. HIFU + FK group was superior to HIFU alone group (P <0.05) in terms of efficiency, progression-free survival and disease control rate. Conclusion: HIFU + FKS is effective in treating advanced hepatocellular carcinoma and its adverse reactions are tolerable.