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目的探讨肾小球滤过率(eGFR)下降与脑卒中类型及预后关系。方法 40例急性脑卒中患者,其中32例为缺血性脑卒中(A组),8例为出血性脑卒中(B组),比较两组eGFR等指标差异;所有患者根据eGFR由低到高分为1组、2组、3组,观察三组预后。结果组间比较,A组患者入院时eGFR显著高于B组,差异有统计学意义(P<0.05),但两组胱抑素C(CysC)、尿酸(UA)、白蛋白(ALB)、血红蛋白(HGB)水平及微量白蛋白尿(UMA)发生率比较差异无统计学意义(P>0.05),入院2周后A组eGFR显著低于B组,差异有统计学意义(P<0.05);组内比较,B组患者入院2周后eGFR显著高于入院时,差异有统计学意义(P<0.05),但A组患者入院时和2周后的eGFR比较差异无统计学意义(P>0.05)。1组患者美国国立卫生研究院卒中量表(NIHSS)评分、死亡率显著高于2、3组,差异有统计学意义(P<0.05),而2组患者的NIHSS评分、死亡率又显著高于3组,差异有统计学意义(P<0.05)。结论 eGFR下降与脑卒中类型及预后密切相关,值得临床充分重视。
Objective To investigate the relationship between glomerular filtration rate (eGFR) decline and stroke type and prognosis. Methods Thirty patients with acute stroke were enrolled in this study. Among them, 32 were ischemic stroke (group A) and 8 were hemorrhagic stroke (group B). The eGFR and other indexes were compared between the two groups. All patients were classified as low to high eGFR Divided into 1 group, 2 groups, 3 groups, observed the prognosis of three groups. Results Compared between the two groups, eGFR in group A was significantly higher than that in group B (P <0.05), but the levels of cystatin C, UA, ALB, The levels of HGB and UMA were not significantly different between two groups (P> 0.05). After 2 weeks of admission, the eGFR of group A was significantly lower than that of group B (P <0.05) (P <0.05). However, the eGFR in group B was significantly higher than that in hospital at 2 weeks after admission (P <0.05), but there was no significant difference in eGFR between group A and 2 weeks after admission > 0.05). The National Institutes of Health Stroke Scale (NIHSS) score and mortality in group 1 were significantly higher than those in groups 2 and 3 (P <0.05), while the NIHSS scores and mortality rates were significantly higher in the two groups In the three groups, the difference was statistically significant (P <0.05). Conclusions The decline of eGFR is closely related to the type and prognosis of stroke, which deserves full attention in clinic.