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巯甲丙脯酸是一种强效血管紧张素转换酶抑制剂。大量的动物实验和临床观察证实,它具有扩张血管,减少钠水潴留的作用,因而改善心功能。本文应用放射免疫方法测定9例巯甲丙脯酸治疗充血性心衰及9例常规治疗充血性心衰前、后血浆心房肽、肾素、血管紧张素Ⅱ的浓度,初步探讨了巯甲丙脯酸对血浆心房肽、肾素、血管紧张素Ⅱ的影响。
Captopril is a potent angiotensin converting enzyme inhibitor. A large number of animal experiments and clinical observations confirm that it has the function of dilating blood vessels and reducing sodium and water retention, thus improving cardiac function. In this paper, radioimmunoassay method for the determination of 9 cases of captopril in congestive heart failure and 9 cases of conventional treatment of congestive heart failure before and after plasma atrial natriuretic peptide, renin, angiotensin Ⅱ concentration, the initial discussion of the mercaptopril Effects of proline on plasma atrial natriuretic peptide, renin and angiotensin Ⅱ.