目的　了解妊娠糖尿病孕妇对围生儿的影响。方法　 32例妊娠糖尿病孕妇所生新生儿及健康对照组 2 0例 ,于出生 4 8h内采取股静脉血标本 ,测定血胰岛素、皮质醇、胰岛素样生长因子 1 (IGF - 1 )。结果　①新生儿早期胰岛素、皮质醇、IGF - 1均较对照组显著增高 (P <0 0 5 ) ;②妊娠糖尿病母亲新生儿早期血糖与对照组比较差异无显著性 (P >0 0 5 ) ;③胎儿柯兴面容、RDS及巨大儿的发生率仍较高。结论　妊娠糖尿病孕妇内分泌水平变化 ,同样对围生儿内分泌水平产生影响 ,血胰岛素、皮质醇、IGF - 1水平出现同时增高现象 ,将影响围生儿生长发育 ,促使体重增加等 ,将影响围生儿生存质量 ,需高度重视 Objective To understand the effect of gestational diabetes mellitus on perinatal children. Methods Twenty - two neonates with gestational diabetes mellitus and 20 healthy pregnant women were enrolled in this study. Femoral venous blood samples were collected within 48 hours after birth and serum insulin, cortisol and insulin - like growth factor 1 (IGF - 1) were measured. Results ① The levels of insulin, cortisol and IGF - 1 in early neonates were significantly higher than those in control group (P <0.05). ② There was no significant difference in early blood glucose between newborn infants with gestational diabetes and control group (P> 0.05) ; ③ fetal Cochin face, RDS and the incidence of huge children is still high. Conclusion The changes of endocrine levels in pregnant women with gestational diabetes also affect the endocrine level of perinatal children. The simultaneous increase of insulin, cortisol and IGF - 1 levels in pregnant women with gestational diabetes mellitus will affect the growth and development of perinatal children and promote weight gain. Children’s quality of life, need to attach great importance