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角膜病是我国一种主要致盲眼病,感染性角膜炎又居角膜病首位,其中单疱病毒感染占63.2％。单一用抗病毒药物对正常细胞有一定毒性,易产生耐药性。我们采用干扰素、利巴韦林(病毒唑)联合治疗,既弥补单一用药的不足,又有效地防治了病毒感染,提高了疗效。 1 资料与方法 1.1 病例选择 我院2年来门诊和住院的疱疹性角膜炎患者56例,男35例,女21例。浅层型35例,深层型21例;初发者38例,复发者18例。发病时间3d～2a,年龄3岁～60岁。 1.2 治疗方法 常规1％地卡因表面麻醉后,利巴韦林100mg(小儿酌减),行下方结膜下注射,qod。配合点0.1％阿昔洛韦(无环鸟苷)眼水,1/2000干扰素眼水辅以0.25％氯霉素眼水,qid.部分严重病例给予肌肉注射或静脉滴注利巴韦林,对于复发重症病例行局麻后用干扰素20万U溶于0.5ml生理盐水中作结膜下注射,每周2次。
Corneal disease is a major cause of blindness in our country, infectious keratitis and the first in the corneal disease, in which herpes simplex virus infection accounted for 63.2%. Single anti-viral drugs have some toxicity to normal cells, easy to produce drug resistance. We use interferon, ribavirin (ribavirin) combination therapy, not only make up for the lack of a single medication, but also effectively control the virus infection and improve the efficacy. 1 Materials and Methods 1.1 Case Selection Our hospital 2 years outpatient and inpatient herpes keratitis patients 56 cases, 35 males and 21 females. 35 cases of superficial type, 21 cases of deep type; 38 cases of primary and 18 cases of recurrence. Onset time 3d ~ 2a, age 3 to 60 years old. 1.2 Treatment Conventional 1% tetracaine anesthesia, ribavirin 100mg (pediatric discretion), line subconjunctival injection, qod. With acyclovir 0.1% acyclovir (acyclovir) eye water, 1/2000 interferon eye water supplemented with 0.25% chloramphenicol eye water, qid. Some serious cases of intramuscular or intravenous infusion of ribavirin , For the recurrence of severe cases of local anesthesia with interferon 200000 U dissolved in 0.5ml saline for subconjunctival injection twice a week.