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ＴＦＤ并用ＨＢＶＡＣ治疗慢性乙型肝炎疗效观察长治市人民医院（０４６０００）张玉凤，张银芳，李均，周潞荣慢性乙型肝炎目前尚无特效的治疗方法，我们采用胸腺因子Ｄ（ＴＦＤ）并用乙肝疫苗（ＨＢＶＡＣ）治疗３４例，收到一定效果，现报告如下：对象与方法一、对象：选择１９９１年３月～１９９２年１０月住院的６７例患者，随机分为两组：一组３４例用ＴＦＤ和ＨＢＶＡＣ治疗（治疗组），一组３３例用综合保肝治疗（对照组）。治疗组３４例中，男２６例，女８例。年龄８～４８岁。病程半年至１０年。按１９９０年全国的病毒肝炎学术会议修订的诊断标准［１］计慢性活动性肝炎（ＣＡＨ）１５例，慢性迁延性肝炎（ＣＰＨ）１９例。对照组３３例中，男２４例，女９例。年龄１２～５３岁。病程半年至１１年。ＣＡＨ１３例，ＣＰＨ２０例。两组病例性别、年龄、病程及分型均无统计学差异。二、治疗方法：治疗组：ＴＦＤ注射液，１０ｍｇ，肌注，每日一次，３月一疗程；ＨＢＶＡＣ，３０ｍｇ肌注，１５天一次，３月一疗程。对照组：只用综合保肝治疗，疗程３月。两组均不用抗病毒药及其它免疫制剂。结果治疗前主要症状和体征两组无明显差异，治疗后治疗组病人的乏力、腹胀、关节酸痛改善均明显好于对照
TFD and treatment of chronic hepatitis B with HBVAC Therapeutic Observation Changzhi People’s Hospital (046000) Zhang Yufeng, Zhang Yinfang, Li Jun, Zhou Lurong There is no specific treatment for chronic hepatitis B, we use thymus factor D (TFD) and hepatitis B vaccine ) Treatment of 34 cases, received some results, are reported as follows: Subjects and methods A, object: Select March 1991 to October 1992 hospitalized 67 patients were randomly divided into two groups: a group of 34 patients with TFD and HBVAC treatment (treatment group), a group of 33 cases with comprehensive hepatoprotective therapy (control group). Treatment group 34 cases, 26 males and 8 females. Age 8 to 48 years old. Course of six months to 10 years. According to the diagnostic criteria revised by the National Conference on Hepatitis A in 1990, 15 cases were chronic active hepatitis (CAH) and 19 cases were chronic persistent hepatitis (CPH). Control group, 33 cases, 24 males and 9 females. Aged 12 to 53 years old. The course of six months to 11 years. 13 cases of CAH, 20 cases of CPH. There was no significant difference in gender, age, course of disease and typing between the two groups. Second, the treatment: the treatment group: TFD injection, 10mg, intramuscular injection, once daily, March a course of treatment; HBVAC, 30mg intramuscular injection, 15 days once a course of treatment in March. Control group: only comprehensive hepatoprotective therapy, treatment in March. Neither antivirals nor other immunosuppressive agents were used in either group. Results Before treatment, there was no significant difference between the two groups in main symptoms and signs. After treatment, the improvement of fatigue, abdominal distension and joint pain in treatment group were significantly better than that of control