急性ST段抬高型心肌梗死患者在溶栓治疗中分别应用瑞替普酶和尿激酶的临床治疗效果

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目的

分析急性ST段抬高型心肌梗死患者在溶栓治疗中分别应用瑞替普酶和尿激酶的临床治疗效果。

方法

选取2019年11月至2020年10月在辽阳市第九人民医院接受治疗的急性ST段抬高型心肌梗死患者98例作为研究对象,根据患者治疗时用药的不同分为对照组和观察组,各49例。对照组男29例,女20例,年龄(65.53±4.83)岁;观察组男28例,女21例,年龄(65.92±4.86)岁。对照组在溶栓治疗时使用尿激酶,观察组在溶栓治疗时使用瑞替普酶。对比两组患者治疗后不同时间血管再通率,溶栓前、后血清基质金属蛋白酶1(MMP-1)、基质金属蛋白酶抑制剂-1(TIMP-1)水平以及心功能指标、并发症发生情况。

结果

观察组溶栓后60 min、90 min、120 min的血管再通率分别为51.02%(25/49)、71.43%(35/49)、93.88%(46/49),均高于对照组20.41%(10/49)、48.98%(24/49)、67.35%(33/49),差异均有统计学意义(均P<0.05)。溶栓前,两组急性ST段抬高型心肌梗死患者血清MMP-1、TIMP-1水平及左心室射血分数(LVEF)、心输出量(CO)等心功能指标比较,差异均无统计学意义(均P>0.05)。溶栓后6 d、12 d,观察组血清MMP-1水平为(5.93±0.39)μg/L、(4.81±0.40)μg/L,TIMP-1水平为(722.54±68.51)μg/L、(627.95±61.42)μg/L,均低于对照组(6.62±0.48)μg/L、(5.51±0.46)μg/L、(755.69±70.33)μg/L、(685.41±66.74)μg/L,差异均有统计学意义(均P<0.05)。溶栓后6 d,观察组LVEF、CO心功能指标分别为(56.61±5.24)%、(4.75±0.44)L/min,均优于对照组(50.37±4.82)%、(3.81±0.36)L/min,差异均有统计学意义(均P<0.05)。观察组并发症发生率为6.12%(3/49),明显低于对照组22.45%(11/49),差异有统计学意义(χ2=5.333,P<0.05)。

结论

急性ST段抬高型心肌梗死在溶栓治疗时使用瑞替普酶,能够显著提高患者血管再通率和各项心功能指标,提高疾病治疗效果,并且并发症较少,治疗安全性高,值得在临床上推广应用。

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