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目的:探讨血液灌流串联血液透析救治急性重度中毒患者的临床疗效。方法:患者44例,随机分为两组。治疗组:在综合治疗的基础上给予血液透析(HD)串联血液灌流(HP)30例;对照组:在综合治疗的基础上,给予单纯血液透析14例。结果:两组治疗后疗效比较,治疗组治愈率达96.67%,与对照组比较差异有显著性。结论:HP与HD是治疗急性中毒最有效方法之一,HP能有效与血浆蛋白竞争药物予以吸收,从而有效、快速将毒物从血液中清除;HD可通过超滤脱水纠正电解质及酸碱失衡,改善脑水肿等并发症。因此,联合使用时有协同作用。
Objective: To investigate the clinical effect of hemoperfusion combined with hemodialysis in the treatment of acute severe poisoning. Methods: 44 patients were randomly divided into two groups. In the treatment group, 30 hemodialysis (HD) serial hemoperfusion (HP) was given on the basis of comprehensive treatment. In the control group, 14 cases were given hemodialysis alone on the basis of comprehensive treatment. Results: The curative effect of the two groups after treatment was 96.67%, which was significantly different from the control group. Conclusion: HP and HD are one of the most effective methods to treat acute poisoning. HP can effectively absorb competing drugs with plasma proteins to effectively and rapidly remove toxicants from the blood. HD can correct electrolyte and acid-base imbalance by ultrafiltration and dehydration, Improve brain edema and other complications. Therefore, there is a synergistic effect when used in combination.