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目的探讨海南黎族脑梗死载脂蛋白E(ApoE)多态性与其危险因素之间是否存在相关性。方法对78例黎族脑梗死患者和74例黎族健康对照者进行一般资料的调查研究;采用聚合酶链式反应—限制性片段长度多态性方法测定ApoE基因型。结果黎族脑梗死患者高血压病、吸烟、卒中家族史、饮酒史、糖尿病等危险因素显著高于健康对照(P<0.05或<0.01),脑梗死患者中危险因素ε3、ε4基因携带明显高于对照者,ε2基因携带明显低于对照者(P<0.01或<0.05)。结论ApoE基因多态性与危险因素之间有相关性,存在协同致病的可能。
Objective To investigate whether there is a correlation between the polymorphism of apolipoprotein E (ApoE) in Hainan Li ethnicity and its risk factors. Methods A total of 78 patients with Li ethnic cerebral infarction and 74 healthy control subjects were investigated. ApoE genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results The risk factors such as hypertension, smoking, family history of stroke, alcohol drinking history and diabetes mellitus were significantly higher in Li people with cerebral infarction than those in healthy controls (P <0.05 or <0.01). The risk factors of ε3 and ε4 were significantly higher in patients with cerebral infarction Control, ε2 gene was significantly lower than the control (P <0.01 or <0.05). Conclusion There is a correlation between ApoE gene polymorphism and risk factors, and there is a possibility of synergistic pathogenicity.