论文部分内容阅读
利用磷光分析法研究了矽宁在家兔体内的药代动力学、生物利用度及血浆蛋白结合率。该法测定生物样品中矽宁含量的灵敏度可达5ng,变异系数为5.57%,平均回收率为83±2%。家兔口服或静注矽宁后,血药浓度-时间的动力学过程符合二室开放式模型。口服给药达峰时间为7.20分钟,表观分布容积较大,组织分布广泛。口服给药的绝对生物利用度为93%。矽宁与小鼠血浆蛋白的结合率为75±2%。
Phosphorescence analysis was used to study the pharmacokinetics, bioavailability and plasma protein binding of Si-ning in rabbits. The method has the sensitivity of 5ng, the coefficient of variation of 5.57% and the average recovery of 83 ± 2% in biological samples. After oral administration of rabbit or intravenous injection of silicon, plasma concentration-time kinetic process in line with two-compartment open model. Oral administration of the peak time of 7.20 minutes, the apparent volume of distribution of large organizations widely distributed. The absolute bioavailability of oral administration was 93%. Silicone and mouse plasma protein binding rate of 75 ± 2%.