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目前治疗移植物抗宿主病(GVHD)的主要问题是:①缺乏特异性的治疗方法,使用免疫抑制剂增加了并发感染的机会;②预防和治疗的药物本身有毒性,对病人可有致命的威胁。为此,人们把研究目标转移到其他免疫抑制剂上,如反应停。反应停在GVHD中的作用 Vogelsang等报告,动物(鼠)的GVHD发生后,用管饲法给反应停,50或/100mg/kg/日,共40天,在23只动物中,22只成功地消除了GVHD。停止反应停治疗后,22只动物中19只未再出现GVHD,其余3只于3周后产生了慢性GVHD.皮肤移植物被接受超过100天,嵌合体得以证实。同样的研究表明,反应停亦可作为预防GVHD的有效药物。移植当天起就给反应停,持续40天,移植后,22只鼠中14只未发生GVHD,其余8只仅有轻微GVHD。这
At present, the main problems in the treatment of graft-versus-host disease (GVHD) are: 1 lack of specific treatment methods, the use of immunosuppressive agents increases the chance of concurrent infection; 2 the prevention and treatment of the drug itself is toxic, can be fatal to the patient Threatened. For this reason, people shift their research goals to other immunosuppressive agents, such as stop of the reaction. The role of the reaction in GVHD was reported by Vogelsang et al. After the occurrence of GVHD in animals (rats), the reaction was stopped by gavage, 50 or 100 mg/kg/day, for a total of 40 days. Of the 23 animals, 22 were successful. Eliminate GVHD. After stopping the thalidomide treatment, 19 out of 22 animals did not develop GVHD, and the remaining 3 developed chronic GVHD after 3 weeks. Skin grafts were accepted for more than 100 days and the chimera was confirmed. The same research shows that the reaction can also be used as an effective drug to prevent GVHD. On the day of transplantation, the reaction was stopped for 40 days. After transplantation, 14 of 22 rats did not develop GVHD, and the remaining 8 had only mild GVHD. This