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据调查研究显示,在我国,中成药在妊娠早期是除了叶酸、维生素和矿物质外,使用最多的药物;在整个妊娠期占妊娠期使用药物的首位[1]。但是随着近年来中药不良反应报道事件的日益增多,人们对中药的安全性提出质疑,特别是妊娠期应用中药,其安全性不仅可以影响母体健康,还关系到子代安全。然而由于历史条件的限制,许多中药上市前未经过严格的生殖毒性及胚胎毒性安全性评估。因此,中药的生殖发育及胚胎毒性研究具有重要
According to the investigation and research, in our country, proprietary Chinese medicines are the most commonly used drugs in pregnancy except folic acid, vitamins and minerals; they account for the first place in pregnancy during pregnancy. However, with the increasing number of reports of adverse reactions of traditional Chinese medicine in recent years, people have questioned the safety of Chinese medicines. In particular, the application of traditional Chinese medicine during pregnancy can not only affect the maternal health but also the safety of offspring. However, due to historical conditions, many traditional Chinese medicines have not undergone strict reproductive toxicity and embryotoxicity safety assessment prior to their listing. Therefore, the reproductive development of traditional Chinese medicine and embryotoxicity is important