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一氧化氮(nitric oxide,NO)在哺乳动物体内的作用最早由Furehgott和Zawadzki于1980年发现,后证实血管内皮细胞可合成NO引起血管扩张。外源性吸入NO(inhaled nitric oxide,iN O)于1999年被FDA批准作为新生儿肺动脉高压的治疗用药。目前公认NO为体内生物活性物质,并在中枢神经系统发挥重要的生理功能[1]。近年来iN O在神经损伤中的作用受到广泛关注,本文拟对iN O在中枢神经系统中作用的研究进展作一综述。
The role of nitric oxide (NO) in mammalian tissues was firstly discovered by Furehgott and Zawadzki in 1980, which confirmed that NO could be induced by vascular endothelial cells to cause vasodilation. Inhaled nitric oxide (NO) was approved by the FDA in 1999 for the treatment of pulmonary hypertension in newborns. NO is currently recognized as the body of bioactive substances, and in the central nervous system to play an important physiological function [1]. In recent years, the role of iN O in nerve injury has received widespread attention. This paper intends to review the role of iN O in the central nervous system.