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目的观察模拟失重效应对下肢肌萎缩的影响及中药红景天的干预作用。方法 16名成年男性健康志愿者随机分为对照组(8人)和用药组(8人),进行45 d-6°头低位卧床模拟长期失重效应实验。卧床期间,用药组和对照组每天分别服用红景天(红益胶囊)和安慰剂。卧床前、中、后动态测量小腿围径;并采用MRI技术,测试和分析卧床前、后大腿和小腿肌群最大横截面积和肌肉体积的变化。结果1)卧床期间用药组和对照组小腿围径进行性下降,在卧床30和45 d均显著下降(P<0.01),但用药组下降幅度显著减少(P<0.05);2)卧床45 d,用药组和对照组大腿和小腿肌肉最大横截面积均显著降低(P<0.01),其中小腿比目鱼肌下降幅度最大。用药组肌肉最大横截面积的减少较对照组均有改善作用(P<0.05);3)对照组大腿和小腿肌群肌肉体积在卧床45 d均显著下降(P<0.01),以比目鱼肌体积下降最为明显,用药组下降幅度显著减少,且比目鱼肌对抗作用最为明显(P<0.01)。结论 45 d-6°头低位卧床引起进行性加重的肌萎缩,中药红景天可部分对抗模拟长期失重效应诱导的下肢肌萎缩。
Objective To observe the effect of simulated weightlessness on lower extremity muscle atrophy and the intervention of Chinese traditional medicine Rhodiola. Methods Sixteen adult male volunteers were randomly divided into control group (n = 8) and medication group (n = 8) for long-term weightlessness at 45 d-6 ° bed rest. During bed rest, the medication group and the control group were given Rhodiola (Hongyi Capsule) and placebo daily. Before, during and after bed rest, the circumference of calf was measured dynamically. The maximum cross-sectional area and muscle volume of thigh and calf muscles before and after bed rest were measured and analyzed by MRI. Results 1) During the ambulatory period, the calf circumference of the medication group and the control group decreased progressively, both at 30 and 45 days of bed rest (P <0.01), but decreased significantly in the medication group (P <0.05); 2) , And the maximum cross-sectional area of thigh and calf muscle in treatment group and control group were significantly decreased (P <0.01), of which the lower leg soleus muscle decreased the most. (P <0.05); 3) The muscle volume of the thigh and calf muscles in the control group decreased significantly (P <0.01) on the 45th day in bed, and the muscle volume in the soleus muscle The decrease was most obvious, and the decreasing rate of medication group was significantly reduced, and the antagonistic effect of soleus muscle was the most obvious (P <0.01). Conclusion 45 d-6 ° head-lying bed caused progressive aggravation of muscle atrophy, Chinese medicine Rhodiola may be part of the fight against simulated long-term weightlessness-induced lower limb muscle atrophy.