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Objective:To investigatetheclinicalandpathologicalfeaturesof idiopathicmembranousnephropathy(IMN)in Chineseadults.Methods:From1986to1997,264patientswithbiopsyprovenmembranousnephropathywereselectedin thisstudy.Clinicalandpathologicalfeatureswerecomparedbetweenpatientsat differentagesby t test.Re sults:(1)Pa-tientsfrom21-40yearsoldwereinclinedto membranousnephropathy.(2)Onehundredandsixof thepatientshadheavy proteinuriaatpresentation.Hypertensionwasfoundin35patients.Renalinsuffciencyoccurredin7.7%of thepatientsin renalbiopsy.Microscopichematuriawas foundin40.2%of thepatients.Seventy-fourpatientspresented nephroticsyn-drome.(3)Eightof the57patientshaddeteriorationof renalfunctionduringan average49-monthfollow-up.(4)Patients of stageⅠ,Ⅱ,ⅢandⅣaccountedfor42.3%,48.7%,6.0%and3.0%respectively.GlomeruliIgG,C 3 andC 1q deposition was foundin93.2%,98.8%and58.3%of thepatients.Conclusion:Youngerpatientsare inclinedto membranous nephropathy.Theincidenceof hypertension,microscopichematuriaandrenalinsuffciencyis similarto thatof othercoun-tries,whilenephroticsyndromeisuncommon.
Objective: To investigatetheclinicalandpathologicalfeaturesof idiopathicmembranousnephropathy (IMN) in Chineseadults.Methods: From1986to1997,264patientswithbiopsyprovenmembranousnephropathywereselectedin thisstudy.Clinicalandpathologicalfeatureswerecomparedbetweenpatientsat differentagesby t test.Re sults: (1) Pa-tientsfrom21-40yearsoldwereinclinedto membranousnephropathy (2) Onehundredandsixof thepatientshadheavy proteinuriaatpresentation.Hypertensionwasfoundin35patients.Renalinsuffciencyoccurredin7.7% of. (4) Patients of stage I, II, III and IVaccounted for 42.3%, 48.7%, 6.0% and 3 (3) Eightof the57patientshaddeteriorationof renalfunctionduringan average49-monthfollow-up. .0% respectively. Glomeruli IgG, C 3 and C 1q deposition was found in 93.2%, 98.8% and 58.3% of the patients. Conflusion: Youngerpatientsare inclined to membranous nephropathy.Theincidence of hypertension, microscop ichematuriaandrenalinsuffciencyis similarto thatof othercoun-tries, whilenephroticsyndromeisuncommon.