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目的 :探讨交界性和恶性卵巢上皮肿瘤微血管生成状态及肿瘤微血管生成与卵巢肿瘤发生、发展的关系。方法 :对 10例交界性卵巢上皮肿瘤和 45例上皮性卵巢癌石蜡组织切片采用 F 相关抗原 ,应用 SABC法 ,检测上皮性卵巢肿瘤中的肿瘤微血管密度 (MVD)。结果 :145例上皮性卵巢癌中 MVD均值为 31.7± 11.2 (4 0 0倍镜下 ) ,高于同时检测的交界性卵巢上皮肿瘤 (P<0 .0 5 )。MVD在不同的卵巢癌临床分期中的差异有显著性意义 (P<0 .0 5 ) ,并且临床 ～ 期肿瘤 MVD高于临床 ～ 期 (P<0 .0 5 )。 2不同组织分级中 MVD无显著性差异 (P>0 .0 5 )。结论 :肿瘤血管生成是卵巢肿瘤发生、发展的早期事件 ,临床 ～ 期的 MVD比 ～ 期高。 MVD与组织分级无明显关系。
OBJECTIVE: To investigate the relationship between the status of microvessel formation in borderline and malignant ovarian epithelial tumors and the occurrence and development of ovarian neoplasms. Methods: F - related antigens were used in 10 cases of borderline ovarian epithelial tumors and 45 cases of epithelial ovarian cancer paraffin sections. SABC method was used to detect the tumor microvessel density (MVD) in epithelial ovarian tumors. Results: The average MVD in 145 cases of epithelial ovarian cancer was 31.7 ± 11.2 (40 times magnification), which was higher than that of the borderline ovarian epithelial tumor (P <0.05). MVD in different clinical stages of ovarian cancer was significantly different (P <0.05), and clinical stage MVD was higher than the clinical stage (P <0.05). There was no significant difference in MVD between different histological grades (P> 0.05). Conclusion: Tumor angiogenesis is an early event in the development and progression of ovarian tumors. MVD in clinical stage is higher than that in stage ~. There was no significant relationship between MVD and histological grade.