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最先从人体分离的美洲钩虫,在乳兔体内完成了整个发育过程(兔株第1代)。这种钩虫在乳兔体内的传代一直延续到第6代,而不用任何免疫抑制剂。2天龄的乳兔对美洲钩虫显示了高度的敏感性。研究结果显示肠道内的钩虫能存活到150天以上,在此期间产卵数是高的。本试验模型检查了由于感染了美洲钩虫所致的白细胞、抗体及血清蛋白反应。结果显示:从第28～170天,嗜酸性粒细胞明显坛多。感染兔株第4代美洲钩虫的乳兔嗜酸性粒细胞坛高的最高峰在第80天(41%)。对感染兔使用对流免疫电泳,用第3期幼虫(兔株)作抗原,能检测出抗美洲钩虫抗体。一般来说,血清内球蛋白总量升高伴有白蛋白的降低。血清蛋白的升高与α_2、β及γ球蛋白组分的升高有关。
The first hookworm, isolated from the human body, completed the entire development in the rabbit (1st generation of rabbit). The passage of this hookworm in the lactating rabbit lasted until passage 6 without any immunosuppressant. 2-day-old rabbit showed high sensitivity to American hookworm. The results show that the hookworms in the gut can survive for more than 150 days, during which time the number of eggs laid is high. This test model examines leucocyte, antibody, and serum protein responses due to infection with hookworms. The results showed that: from 28 to 170 days, eosinophils significantly more altar. The highest albino eosinophil peak in rabbits infected with the 4th generation hookworm of H. armigera was on day 80 (41%). Conjugate immunocompetent rabbits were used to detect antibodies against hookworms against the 3rd instar larvae (rabbit strain) as antigen. In general, elevated serum globulin is accompanied by a decrease in albumin. Serum protein and α 2, β and γ globulin components of the increase.