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毫微粒是很有前途的给药系统。它之所以优于脂质体、乳剂等其它胶粒载体系统,是因其原料来源广,制法多,可用冻干法制备以增加微粒的稳定性。目前毫微粒的靶向性仅局限于网状内皮系统,毫微粒用某种血清成份包衣,连接抗体或亚砜基以及采用磁性毫微粒,有可能改变其体内分布。是一种很有希望的细胞抑制剂载体。1.制备毫微粒的原料与方法的选择毫微粒制法的选择主要取决于药物的性质。疏水性药物应采用连续水相法,亲水性药物
Nanoparticles are promising delivery systems. The reason why it is better than liposomes, emulsions and other colloidal particle carrier system, because of its wide source of raw materials, system of law, can be prepared by freeze-drying method to increase the stability of particles. Currently the targeting of nanoparticles is confined to the reticuloendothelial system, where the nanoparticles are coated with a serum composition, antibodies or sulfoxides, and magnetic nanoparticles, potentially altering their distribution in vivo. Is a promising vector for cytostatics. 1. Preparation of nanoparticles and the choice of raw materials Nanoparticles Preparation depends on the choice of the nature of the drug. Hydrophobic drugs should be continuous aqueous method, hydrophilic drugs