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对２１例高脂血症单纯性肥胖儿童血浆前列环素（ＰＧＩ２）代谢产物６－酮－ＰＧＦ１α、血栓素（ＴＸＡ２）降解产物ＴＸＢ２及β－血小板球蛋白（β－ＴＧ）进行了定量分析，结果表明高脂血症肥胖儿较２１例正常儿童血浆６－酮－ＰＧＦ１α明显降低（Ｐ＜０．０１），血浆６－酮－ＰＧＦ１α／ＴＸＢ２比值亦明显变小（Ｐ＜０．０１），血浆β－ＴＧ显著升高（Ｐ＜０．０１）。提示高脂血症肥胖儿童血小板释放反应明显增强，并与体内ＰＧＩ２含量减少及ＰＧＩ２／ＴＸＡ２比值下降有关。
The metabolites 6-keto-PGF1α, TXB2 and β-thromboglobulin (β-TG) of PGI2 in 21 obese hyperlipidemic obese children were quantitatively analyzed. The results showed that the plasma levels of 6-keto-PGF1α in hyperlipidemic obese children were significantly lower than those in 21 normal children (P <0.01), and the ratios of 6-keto-PGF1α / TXB2 in plasma were significantly decreased (P <0.01) Plasma β-TG was significantly higher (P <0.01). The results suggest that platelet release response in obese children with hyperlipidemia is significantly increased, which is related to the decrease of PGI2 content and the decrease of PGI2 / TXA2 ratio in vivo.