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弓形体是一种专性寄生在细胞内的原虫,其感染遍及全球。该病可通过母婴垂直传播,引起先天发育异常,造成脑畸形、缺损,严重时可导致流产或死胎。近年来由于受滋病(AIDS)的发现,大约有5～10％的AIDS病患者合并弓形体病,两者的密切关系已引起国外学者的极大关注。可见对弓形体病的研究就更具有现实意义。而NK(自然杀伤)细胞在抗御肿瘤与病毒感染中起着重要作用,国外学者近几年来用小鼠等动物进行了较多研究。本文仅对弓形体(TP)感染时NK细胞活性变化、有关影响因素和研究现状作一概述。
Toxoplasma is an obligate protozoan parasites in the cell, its infection throughout the world. The disease can be transmitted vertically through mother and baby, causing congenital dysplasia, resulting in brain deformity, defects, severe cases can lead to miscarriage or stillbirth. In recent years, about 5% to 10% of AIDS patients have been diagnosed with AIDS due to the discovery of AIDS. The close relationship between them has drawn great attention from foreign scholars. Shows that the study of toxoplasmosis more practical significance. However, NK (natural killer) cells play an important role in the fight against tumor and virus infection. In recent years, foreign scholars have done more researches on mice and other animals. This article only on Toxoplasma (TP) infection of NK cell activity changes, the influencing factors and research status are summarized.