论文部分内容阅读
近年来国内对国产磺胺药和TMP的药理研究,包括抗菌作用,药动学和毒性研究等都取得不少成绩,为临床推广应用提供了资料单用SD、SMZ、DS一36、SIZ等对脑膜炎球菌和伤寒杆菌有强大的抗菌作用,对肺炎球菌的作用也较强.SD仍是流脑的首选药物,且不需加用TMP.磺胺药与TMP合用时远远大于单用的抗菌作用,为抗感染治疗提供了新的途径.磺胺药与TMP合用药敏与临床疗效符合率可达80%,较常用抗生素的符合率70%为高,可供临床应用时参考.
In recent years, the domestic domestic sulfa drugs and TMP pharmacological studies, including antibacterial effects, pharmacokinetics and toxicity studies have achieved many achievements for the clinical application of a single data sheet with SD, SMZ, DS-36, SIZ and so on Meningococci and typhoid bacillus have a strong antibacterial effect on the role of pneumococcus is also strong .SD is still the preferred drug of meningitis, and without the addition of TMP. Sulfa drugs and TMP combined far greater than the single antimicrobial And provide a new way for the anti-infective treatment.Sulfa drug and TMP combined with drug sensitivity and clinical efficacy in line with the rate of up to 80%, 70% compared with commonly used antibiotics for high reference for clinical applications.