本文合成了４－（喹啉８＇－甲基）－１，４，７，１０－四氮杂环十三烷－１１，１３－二酮．测定了该配体和４－（吡啶－２＇－甲基）－１，４，７，１０－四氮杂环十三烷－１１，１３－二酮配体的质子化常数及它们与ＣＵ（Ⅱ）形成的二元配合物，与Ｃｕ（Ⅱ）－ｂｉｐｙ形成的三元配合物的稳定常数．还合成了４－（喹啉－８＇－甲基）－１，４，８，１１－四氮杂环十四烷－１２，１＇４－Ｍ酮配体，测定了该配体的质子化常数及其与Ｃｕ（Ⅱ）形成的二元配合物的稳定常数．讨论并比较了这类带有功能性侧基的二氧四胺大环新型配体在水溶液中与Ｃｕ（Ⅱ）的配位能力、配位方式和相应配合物的空间构型． In this paper, 4- (quinoline 8’-methyl) -1,4,7,10-tetraazacyclotridecane-11,13-dione was synthesized. The protonation constants of this ligand and 4- (pyrid-2’-methyl) -1,4,7,10-tetraazacyclotridecane-11,13-dione ligand and their correlation with the CU (Ⅱ) formed by the binary complex with Cu (Ⅱ) -bipy formation of ternary complex stability constants. A 4- (quinoline-8’-methyl) -1,4,8,11-tetraazacyclotetradecane-12,1’4-M ketone ligand was also synthesized, and the proton Chemical Constants and Stability Constants of Binary Complex with Cu (Ⅱ). The coordination ability, coordination mode and the spatial configuration of the corresponding complexes of the novel dioxytetraamine macrocyclic ligands with functional pendant groups in aqueous solution were discussed and compared.