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目的:探讨急性脑梗死患者外周血sE-选择素、sL-选择素表达水平的变化、临床意义。方法:对30例急性脑梗死患者采用酶联免疫吸附技术(ELISA)定量测定发病<72h、7天时外周血血清sE-选择素、sL-选择素的表达水平,并与20例健康者作对照。结果:发病<72h、7天时外周血sE-选择素的表达水平分别为(10.49±8.70)ng/ml、(5.74±4.40)ng/ml,均显著高于对照组(均P<0.01);且与发病<72h相比,发病7天时下降明显,其差异有显著性(P<0.01)。发病<72h、7天时外周血sL-选择素的表达水平分别为(4.29±2.22)ng/ml、(4.27±2.11)ng/ml,均显著低于对照组(均P<0.01);7天与<72h相比其表达水平差异无显著性(P>0.05)。结论:急性脑梗死时患者外周血sE-选择素表达上调而sL-选择素表达下调;它们可能参与了急性脑梗死的病理过程,对临床治疗有参考价值。
Objective: To investigate the changes and clinical significance of sE-selectin and sL-selectin in peripheral blood of patients with acute cerebral infarction. Methods: Serum levels of sE-selectin and sL-selectin in peripheral blood were determined by enzyme-linked immunosorbent assay (ELISA) in 30 patients with acute cerebral infarction. The serum levels of sE-selectin and sL- . Results: The expression levels of sE - selectin in peripheral blood were significantly lower than those of the control group at 72 h and 7 days (10.49 ± 8.70 ng / ml and 5.74 ± 4.40 ng / ml, respectively (all P <0.01; Compared with the incidence of <72h, the incidence decreased significantly at 7 days, the difference was significant (P <0.01). The levels of sL-selectin in peripheral blood were significantly lower than those in control group at 72 h and 7 days (4.29 ± 2.22 ng / ml, 4.27 ± 2.11 ng / ml, all P <0.01) Compared with <72h, there was no significant difference in the expression level (P> 0.05). Conclusion: In patients with acute cerebral infarction, sE-selectin expression is up-regulated and sL-selectin expression is down-regulated. They may be involved in the pathological process of acute cerebral infarction and have reference value for clinical treatment.