论文部分内容阅读
多发性硬化(MS)是一种自身免疫性疾病,其发病机制尚不明确,可能是多因素共同致病的结果。自噬,即细胞内的“自食”现象,可清除细胞内多余的细胞器和蛋白质,是维持机体正常生理功能的重要机制。近年研究发现,自噬参与了MS和实验性自身免疫性脑脊髓炎(EAE)的发生发展过程,EAE是一种用中枢神经系统髓鞘抗原免疫易感动物的自身免疫性疾病模型,是目前最常用于研究MS的动物模型。对自噬的干预有望能为阐明MS的发病机制和开发更多治疗措施提供新的依据,文中就自噬在MS中的研究进展做一综述。
Multiple sclerosis (MS) is an autoimmune disease, its pathogenesis is not clear, may be the result of multiple factors together. Autophagy, the intracellular “self-contained” phenomenon, can remove excess cellular organelles and proteins in the cells and is an important mechanism to maintain the normal physiological functions of the body. Recent studies have found that autophagy is involved in the development and progression of MS and experimental autoimmune encephalomyelitis (EAE), a model of autoimmune disease that is susceptible to central nervous system myelin antigens Most commonly used to study animal models of MS. The intervention of autophagy is expected to provide a new basis for elucidating the pathogenesis of MS and developing more therapeutic approaches. In this paper, the progress of autophagy in MS is reviewed.