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The G-quadruplexes formed from G-rich strands in the telomere and oncogene-promoter regions are regarded as new promising targets in the cancer therapy.A G-quadruplex in the downstream flanking region of the signal transducer and activator of transcription 3(STAT3) gene was explored.Its folding patterns were proposed to be 3:2:2 and 3:3:1 loop isomers by the mutation analysis by CD spectroscopy.The structures were constructed and refined by molecular modeling method.
The G-quadruplexes formed from G-rich strands in the telomere and oncogene-promoter regions are as as promising precursors in the cancer therapy. A G-quadruplex in the downstream flanking region of the signal transducer and activator of transcription 3 (STAT3) gene was explored.Its folding patterns were proposed to be 3: 2: 2 and 3: 3: 1 loop isomers by the mutation analysis by CD spectroscopy. The structures were constructed and refined by molecular modeling method.