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目的 了解广州市孕妇 (孕中、晚期 )碘营养状况。方法 用砷 -铈接触法测定尿碘 ,用放射免疫分析法 (RIA )测定血清甲状腺素 (T4 )、促甲状腺激素 (TSH )。结果 孕妇孕中期尿碘中位数为 2 4 9.3μg/ L ,<10 0μg/ L者占 4 .5 % ;孕晚期尿碘中位数为 2 4 1.2μg/ L ,<10 0μg/ L者占 12 .5 % ,两期尿碘值差异无显著意义 (P >0 .0 5 )。孕中期血清 T4 (15 7.0± 6 6 .4 ) nmol/ L ,在正常范围 (5 4～ 174 nm ol/ L )者占 5 8.2 % ,超过 174 nmol/ L者占38.8% ;孕晚期血清 T4 (12 4 .4± 5 9.4 ) nm ol/ L ,在正常范围者占 78.3% ,超过 174 nmol/ L者占 13.0 %。孕中期血清 TSH (中位数 3.9m U / L ) <5 m U / L者占 6 5 .7% ,>5 m U / L者占 34.3% ;孕晚期血清 TSH (中位数 6 .9m U / L ) <5 m U/ L者占 18.2 % ,>5 m U / L者占 81.8%。两期自身对照 TSH>5 m U / L与 <5 m U / L人数构成差异有非常显著意义 (P <0 .0 1)。结论 广州市孕妇碘营养状况良好 ;孕晚期血清 TSH>5 m U / L者 (81.8% )较多 ,与尿碘、T4 水平不一致 ,有待进一步研究
Objective To understand the status of iodine nutrition in pregnant women (middle and late pregnancy) in Guangzhou. Methods Urine iodine was determined by arsenic - cerium contact method, serum thyroxine (T4) and thyrotropin (TSH) were measured by radioimmunoassay (RIA). Results The median urinary iodine of pregnant women in the second trimester was 2 4 9.3 μg / L, while that of <10 0 μg / L was 4.5%. The median urinary iodine of pregnant women was 2 4 1.2 μg / L, <10 0 μg / L Accounting for 12.5%. There was no significant difference in urinary iodine value between the two groups (P> 0.05). The gestational T4 (15 7.0 ± 6.64) nmol / L in the second trimester accounted for 52.2% in the normal range (54-174 nmol / L) and 38.8% in the second trimester (12.4 ± 5 9.4) nm ol / L, accounting for 78.3% in the normal range and 13.0% in those with more than 174 nmol / L. The second trimester serum TSH (median 3.9 mU / L) <5 mU / L accounted for 65.7%,> 5 mU / L accounted for 34.3%; third trimester serum TSH (median 6.9 m U / L) <5 m U / L accounted for 18.2%,> 5 m U / L accounted for 81.8%. Two self-control TSH> 5 mU / L and <5 m U / L constitute a significant difference (P <0. 01). Conclusion Pregnant women in Guangzhou have good iodine nutrition status. The third trimester pregnancy serum TSH> 5 mU / L is more (81.8%), which is inconsistent with the urinary iodine and T4 levels and needs further study