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目的 :探讨甲型与戊型肝炎肝细胞损害程度的差异和检测血清 β2 -微球蛋白 ( β2 -MG)的临床意义。方法 :对血清β2 -MG水平与发病年龄、血清主要生化指标作相关分析 ,对甲型与戊型肝炎血清β2 -MG水平进行比较。结果 :血清β2 -MG水平与发病年龄无相关性 ( P >0 .0 5 ) ;戊型肝炎血清 β2 -MG水平显著高于甲型肝炎 ( P <0 .0 1) ;血清 β2 -MG水平与丙氨酸转氨酶和总胆红素均无相关性 ( P >0 .0 5 ) ,与白蛋白呈负相关 ( P <0 .0 0 1)。结论 :发病年龄对血清β2 -MG水平无明显影响 ;戊型肝炎肝脏炎症和损害程度较甲型肝炎重 ;检测血清β2 -MG可间接反映肝细胞损害程度 ,但不是判断肝细胞损害程度的敏感指标。
Objective: To investigate the difference of hepatocellular damage between type A and hepatitis E and the clinical significance of detecting serum β2 - microglobulin (β2 - MG). Methods: Serum β2-MG levels and age of onset, serum biochemical indicators for the correlation analysis of hepatitis A and hepatitis E β2 -MG levels were compared. Results: Serum β2-MG level had no correlation with age at onset (P> 0.05); serum β2-MG level in hepatitis E was significantly higher than that in hepatitis A (P <0.01); serum β2-MG level There was no correlation between alanine aminotransferase and total bilirubin (P> 0.05), but negatively correlated with albumin (P <0.01). Conclusion: The age of onset has no significant effect on the level of serum β2-MG. Hepatic inflammation and damage of hepatitis E are more serious than that of hepatitis A. Detection of serum β2-MG may indirectly reflect the degree of hepatocellular damage, but it is not sensitive to determine the degree of hepatocellular damage index.