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肝细胞癌患者即使给以低脂膳食,亦常有高胆固醇血症,迄今机理不明。设想有两种可能性:(一)肝内胆汁郁积所致;(二)肝癌细胞缺乏调节胆固醇合成的反馈调节系统。作者通过测定血清鲨烯浓度变化,对胆固醇的合成过程作了定量研究,以阐明肝癌病人高胆固醇血症的发生机理。实验对象分三组;健康对照组和肝癌病人各15例,胆汁郁积患者9例。肝癌病人中8例有组织学诊断,其余7例系经甲胎蛋白(AFP)、~(99m)Tc硫,~(198)Au胶体闪烁图谱及腹腔动脉造影所确诊。胆汁郁积肝病一组包括:病毒性胆汁郁积性肝炎,原发性胆汁郁积性肝硬变、胆总管结石症,及胰头癌。于早晨空腹取静脉血,-20℃保存待用。胆固醇按常规测定,并用
HCC patients often have hypercholesterolemia even though they are given a low-fat diet, so far the mechanism is unknown. Imagine two possibilities: (a) cholestasis due to intrahepatic cholestasis; (b) liver cancer cells lack a feedback regulation system that regulates cholesterol synthesis. By measuring the change of serum squalene concentration, the author made a quantitative study on the synthesis of cholesterol to clarify the mechanism of hypercholesterolemia in patients with liver cancer. Subjects were divided into three groups; healthy control group and liver cancer patients in 15 cases, cholestasis in 9 cases. Eight of the patients with hepatocellular carcinoma had a histological diagnosis, and the remaining seven were diagnosed by AFP, ~ 99m Tc, ~ (198) Au colloid scintigraphy and celiac angiography. A group of cholestatic liver diseases include viral cholestatic hepatitis, primary cholestatic cirrhosis, choledocholithiasis, and pancreatic head cancer. Fasting blood in the morning to take, -20 ℃ preserved for use. Cholesterol by conventional determination, and use