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目的:评估高压氧早期干预新生儿缺血缺氧性脑病的作用。方法:收集2009年1月至2012年12月高州市人民医院收治的381例缺血缺氧性脑病新生儿,分为对照组(199例)和治疗组(182例)。采用运动发育量表PDMS-2评估治疗效果。结果:治疗组治疗后的GMQ、TMQ评分优于对照组(P<0.05),后遗症发生率低于对照组(P<0.05)。结论:对于新生儿缺血缺氧性脑病,高压氧早期干预能起到明显的治疗效果,但必须明确高压氧治疗的适应证,以减小可能带来的并发症。
OBJECTIVE: To assess the role of hyperbaric oxygen in early intervention of neonatal hypoxic-ischemic encephalopathy. Methods: A total of 381 newborns with hypoxic-ischemic encephalopathy admitted from Gaozhou People’s Hospital from January 2009 to December 2012 were divided into control group (n = 199) and treatment group (n = 182). The PDMS-2 was used to assess the effect of treatment. Results: After treatment, the scores of GMQ and TMQ in the treatment group were better than those in the control group (P <0.05). The incidence of sequelae was lower in the treatment group than in the control group (P <0.05). Conclusion: Early intervention with hyperbaric oxygen can play a significant therapeutic effect on neonatal hypoxic-ischemic encephalopathy. However, indications of hyperbaric oxygen therapy must be clarified so as to reduce the possible complications.