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作者选择53名年龄为18～40岁(平均26.8岁)的乙型肝炎病毒(HBV)标志阴性、丙氨酸转氨酶(ALT)正常的健康医务人员为研究对象,将他们随机分到0、1和6个月免疫程序(常规组)和0、2和6周免疫程序(短程组)两个组中,于上臂三角肌接种美国Merck药厂生产的重组乙型肝炎(HB)疫苗(10μg/ml)。每次接种后5天内测量体温,同时询问局部反应和全身症状,于第1针后2、4、6和8周及6、7和12个月采血,测定HBsAg、抗-HBs和抗-HBc,第8周的标本也测定ALT。以放射免疫法测定免疫后血清中抗-
We selected 53 health-care workers who were negative for hepatitis B virus (HBV) and normal for alanine aminotransferase (ALT), aged 18-40 years (average 26.8 years), and were randomized to 0,1 (10 μg / kg) were administered to the deltoid muscle of the upper arm in two groups of immunization program (routine group) and 0, 2 and 6 weeks of immunization (short-term group) ml). Body temperature was measured within 5 days of each inoculation, while local reactions and systemic symptoms were also examined. Blood samples were collected at 2, 4, 6 and 8 weeks and 1, 6, 7 and 12 months after the first injection to determine HBsAg, anti-HBs and anti-HBc The 8th week also measured ALT. Immunoassay after the determination of serum anti-immune -