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８２２例首次急性心肌梗塞症状后７２小时内入院且无心源性休克患者中，４７８例自入院后开始并于随访期持续接受常规及卡托普利治疗（甲组），３４４例单纯接受常规治疗（乙组）。住院期间中，甲组病死率（６．９％）明显低于乙组（１８％）（Ｐ＝０．００１），且心肌梗塞前壁或（和）下壁具相似作用（前壁：６．８％和１８．３％，Ｐ＜０．００１；下壁：６．４％和１３．５％，Ｐ＜０．０５；前壁＋下壁：１０．７％和３９．２％，Ｐ＜０．０３）。随访期（平均２０个月）中，尽管两组再梗塞和严重心律失常发生率相似，但甲组的病死率（２．３％和１６．２％，Ｐ＝０．０３２４）和总心脏性事件发生率（１０．３％和３７．４％，Ｐ＝０．０５５）显著低于乙组。因此，急性心肌梗塞后早期并持续应用血管紧张素转换酶抑制剂－卡托普利治疗对患者的预后具有益作用。
Of the 822 patients admitted to hospital within 72 hours after first acute myocardial infarction and without cardiogenic shock, 478 patients started post-admission and continued to receive routine and captopril treatment during follow-up (arm A) and 344 patients received simple routine treatment (Group B). During hospitalization, the mortality in group A (6.9%) was significantly lower than that in group B (18%) (P = 0.001), and the anterior or / and inferior wall of myocardial infarction had a similar effect (anterior wall: 6 .8% and 18.3%, P <0.001; lower wall: 6.4% and 13.5%, P <0.05; anterior wall + inferior wall: 10.7% and 39.2% P <0.03). During the follow-up period (mean 20 months), the mortality in group A (2.3% vs 16.2%, P = 0.0324) and total cardial heart failure were similar despite the similar incidence of reinfarction and severe arrhythmia Incidence rates (10.3% and 37.4%, P = 0.055) were significantly lower than those in group B. Therefore, the early and sustained application of angiotensin-converting enzyme inhibitor-captopril after acute myocardial infarction has a beneficial effect on the prognosis of patients.