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[目的]探讨静脉结合皮下注射葡萄糖酸钙(CG)治疗氢氟酸烧伤的疗效及安全性。[方法]2006年1月至2013年8月共收治82例氢氟酸烧伤患者。在入院时创面皮下一次性注射CG,剂量为30~45 mg/cm2者9例,10~30 mg/cm232例,5~10 mg/cm2 41例;Ⅰ度创面按0.25~5.00 mg/cm2的剂量皮下注射或采用2.5%CG溶液湿敷。皮下注入CG总量1~5 g者57例,5~10 g 14例,10~20 g 10例,20~30 g 1例。同时动态监测血钙,根据血钙调整静脉补钙速度。[结果]82例氢氟酸烧伤患者均治愈。5例低钙血症患者在入院后4 h内得到纠正,71例患者血钙维持在正常范围,6例患者出现高钙血症。所有患者经过1个月以上随访,注射区域未见感染、皮下结节形成和皮肤坏死,也未见创面明显加深现象。[结论]静脉结合皮下注射CG是救治氢氟酸烧伤的有效方法,但皮下注射剂量应根据患者的伤情加以调整,避免剂量过大发生高钙血症。
[Objective] To investigate the efficacy and safety of intravenous injection of calcium gluconate (CG) in the treatment of hydrofluoric acid burns. [Methods] From January 2006 to August 2013, 82 patients with hydrofluoric acid burns were treated. At the time of admission, CG was given subcutaneously in the skin subcutaneously at a dose of 30-45 mg / cm2 in 9 cases, 10-30 mg / cm2 in 232 cases and 5-10 mg / cm2 in 41 cases. The first degree wounds were treated with 0.25-5.50 mg / cm2 Dose subcutaneous injection or 2.5% CG solution wet compress. Subcutaneous injection of CG total 1 to 5 g in 57 cases, 5 to 10 g in 14 cases, 10 to 20 g in 10 cases, 20 to 30 g in 1 case. At the same time dynamic monitoring of serum calcium, calcium adjustment according to the speed of intravenous calcium. [Results] 82 cases of hydrofluoric acid burns were cured. Five patients with hypocalcemia were corrected within 4 h after admission, 71 patients with serum calcium remained in the normal range, and 6 patients had hypercalcemia. All patients after more than 1 month follow-up, no infection in the injection area, subcutaneous nodules and skin necrosis, but also no significant wound deepening phenomenon. [Conclusion] Intravenous and subcutaneous injection of CG is an effective method for the treatment of hydrofluoric acid burns. However, the dosage of subcutaneous injection should be adjusted according to the patient ’s injury so as to avoid hypercalcemia.